BrowseBiology & Medicine / Genetics & Cell Biology

DNA vs RNA

DNA and RNA are chemically close relatives used for very different jobs.

Diagram comparing structural differences between DNA and RNA.
Wikimedia Commons
DNARNA
Sugardeoxyriboseribose
Basethymine (T)uracil (U)
Usual formdouble-strandedoften single-stranded
Typical roledurable information archivemessage, regulator, structure, catalyst

The small chemical difference matters. RNA's ribose has an extra 2-prime-OH group. That hydroxyl can participate in cleavage of the phosphodiester backbone, making RNA more prone to hydrolysis than DNA. Removing that oxygen in deoxyribose helps make DNA better suited to long-term information storage.

RNA is not merely "a disposable DNA copy." Messenger RNA carries coding information, but ribosomal RNA forms catalytic/structural machinery, transfer RNA delivers amino acids, and many other RNAs regulate gene expression.

A useful analogy is therefore:

DNA = archive; RNA = working molecular ecosystem built from selected information in the archive.

connected to

sources

NHGRI, RNA Fact SheetNHGRI, DNANCBI Bookshelf, RNA backbone stability